Lesion – symptom mapping

In order to understand the neural substrates for any given brain function under investigation, many studies in cognitive neuroscience employ functional brain imaging techniques. Lesion-based neuropsychology research has the unique advantage of investigating not just which areas of the brain are involved when we do a particular task or think about a particular thing, but crucially which areas are necessary. By researching large groups of stroke survivors with a variety of resulting brain areas damaged, we can use this data to better understand the neural underpinnings of behaviour.


  • [PDF] Haupt, M., Gillebert, C. R., & Demeyere, N.. (2017). The zero effect: voxel-based lesion symptom mapping of number transcoding errors following stroke. Scientific reports, 7(1), 9242.
  • [PDF] Varjačić, A., Mantini, D., Levenstein, J., Slavkova, E. D., Demeyere, N., & Gillebert, C. R.. (2018). The role of left insula in executive set-switching: lesion evidence from an acute stroke cohort. Cortex, 107, 92–101.
  • [PDF] Chechlacz, M., Novick, A., Rotshtein, P., Bickerton, W., Humphreys, G. W., & Demeyere, N.. (2014). The neural substrates of drawing: a voxel-based morphometry analysis of constructional, hierarchical, and spatial representation deficits. Journal of cognitive neuroscience, 26(12), 2701–2715.


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